The 23-year-old France U21 international has caught the attention of several top European clubs this year.
According to sources close to the club, Newcastle are making a serious attempt to secure Ekitike's services, which could involve a record-breaking transfer fee for the striker.
Insiders suggest that Newcastle are willing to exceed the £70 million mark to bring Ekitike on board, where he would join forces with Alexander Isak, rather than replacing him.
Ekitike had a notable season last year, scoring 15 goals and providing eight assists, and he remains contracted to Frankfurt until 2029.