He takes over from Giovanni Stroppa, who decided to leave the team after guiding them to promotion from Serie B, the second division, last season.
Nicola previously left Cagliari, another team in Serie A, after helping them avoid relegation with a short-term deal last term.
The club praised Nicola for his ability to define a clear playing style and motivate his players, saying he is the perfect fit to lead the team in the challenging Serie A league.
Cremonese's owners and the team welcome Nicola and wish him good luck in his new role.